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	Provedor de dados Biol. Res. (2) Autor CAVIEDES,PABLO (2) CAVIEDES,RAÚL (2) ARRIAGADA,CHRISTIAN (1) CÁRDENAS,ANA MARÍA (1) FERREIRA,SERGIO T (1) LIMA,ANDRÉA C PAULA (1) RAPOPORT,STANLEY I (1) TORO,RODRIGO (1) Mais... Palavra-chave Down syndrome (2) Alzheimer's disease (1) Calcium current (1) Dorsal root ganglion (1) Intracellular amyloid (1) Murine trisomy 16 (1) Patch clamp (1) Small molecule inhibitors (1) Tissue culture (1) Trisomy 16 (1) Mais... Tipo do documento Journal article (2) Ano 2008 (1) 2006 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Altered calcium currents in cultured sensory neurons of normal and trisomy 16 mouse fetuses, an animal model for human trisomy 21 (Down Syndrome) Biol. Res. CAVIEDES,PABLO; CAVIEDES,RAÚL; RAPOPORT,STANLEY I. Down syndrome is determined by the presence of an extra copy of autosome 21 and is expressed by multiple abnormalities, with mental retardation being the most striking feature. The condition results in altered electrical membrane properties of fetal dorsal root ganglia (DRG) neurons, as in the trisomy 16 fetal mouse, an animal model of the human condition. Cultured trisomic DRG neurons from human and mouse fetuses present faster rates of depolarization and repolarization in the action potential compared to normal controls and a shorter spike duration. Also, trisomy 16 brain and spinal cord tissue exhibit reduced acetylcholine secretion. Therefore, we decided to study Ca2+ currents in cultured DRG neurons from trisomy 16 and age-matched control mice, using... Tipo: Journal article Palavras-chave: Trisomy 16; Dorsal root ganglion; Calcium current; Tissue culture; Patch clamp; Down syndrome. Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300009 Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line Biol. Res. LIMA,ANDRÉA C PAULA; ARRIAGADA,CHRISTIAN; TORO,RODRIGO; CÁRDENAS,ANA MARÍA; CAVIEDES,RAÚL; FERREIRA,SERGIO T; CAVIEDES,PABLO. We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now evaluated the effects of such compounds on amyloid precursor protein (APP) accumulation in the CTb immortalized cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down's syndrome. Compared to a non-trisomic cortical cell line (CNh), CTb cells overexpress APP and exhibit slightly elevated resting intracellular Ca2+ levéis ([Ca2+]¡). Here, we show that the compounds 2,4-dinitrophenol, 3-nitrophenol and 4-anisidine decreased intracellular accumulation of APP in CTb cells. Those compounds were non-toxic to the cells, and... Tipo: Journal article Palavras-chave: Alzheimer's disease; Down syndrome; Intracellular amyloid; Murine trisomy 16; Small molecule inhibitors. Ano: 2008 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200001 Registros recuperados: 2 Primeira ... 1 ... Última

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